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The Effects of Physical Exercise and Cognitive Training on Memory and Neurotrophic Factors

The next lecture I will be giving will probably be in September of 2020. I know that seems a bit far away. The lecture will be titled, “Exercise, Diet, and Cognitive Function Over the Life Span.” There is an enormous about of data that has been published on these topics, including older and newer research. I will be trickling out a few of the more relevant studies over the next several months. So, watch this space.

The next lecture I will be giving will probably be in September of 2020. I know that seems a bit far away. The lecture will be titled, “Exercise, Diet, and Cognitive Function Over the Life Span.” There is an enormous about of data that has been published on these topics, including older and newer research. I will be trickling out a few of the more relevant studies over the next several months. So, watch this space.

The Effects of Physical Exercise and Cognitive Training on Memory and Neurotrophic Factors
Jennifer J. Heisz, Ilana B. Clark, Katija Bonin, Emily M. Paolucci,
Posted Online September 29, 2017
https://doi.org/10.1162/jocn_a_01164

This study examined 95 subjects that participated in one of three groups:

1. High intensity interval training (20 minutes, 3 times per week, for 6 weeks)
2. High intensity interval training combined with cognitive training,
3. Control group.

Both experimental groups demonstrated increases in high interference memory along with a concurrent increase in BDNF (brain derived neurotrophic factor) and IGF-1, while the control group had no increase. BDNF is a neurotrophic factor that regulates synaptic plasticity, which is necessary for high interference memory.

high_interference


Subjects showing greater physical improvement (high responders), also experienced greater increases in BDNF, IGF-1 and high interference memory scores as compared to low responders. High interference memory is the type of memory that allows us to distinguish small difference between two objects, for example our car of certain make and model from another car of that same make and model. In older subjects, the loss of high interference memory and decreases in BDNF may correlate with the onset of cognitive impairment.

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